To Spike or Not to Spike: That Is the Question

To Spike or Not to Spike: That Is the Question

Both the brain and digital computers process information, but they do this in completely different ways. Neurons in the brain transmit information not through bits, but through spikes. Spikes are short voltage increases [see inset in the figure above] that are generated near the cell body of a neuron, with average spike rates below 10 Hz. These spikes are transmitted via fine axonal fibers and ...

coeliac disease: to classify or not to classify – that is the question!

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the student committee of sports medicine research center: to be independent or not to be? that is the question

To scavenge or not to scavenge: that is the question.

Analysis of a series of diffraction data sets measured from four native as well as four nicotinic acid-soaked crystals of trypsin at 100 K shows a high variability in radiation-sensitivity among individual crystals for both nicotinic acid-soaked and native crystals. The level of radiation-sensitivity and the extent of its variability is statistically indistinguishable between the two conditions...

To P or not to P: that is the question.

In 1993 Eugene Harris, a well-known biostatistician at the NIH, wrote an editorial for Clinical Chemistry regarding the use of P values vs confidence intervals in the evaluation of scientific data (1 ). This has long been a contentious topic in the scientific world and one with which each new generation of scientists has had to grapple on the basis of arguments advanced for the use of various s...